Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
Rethinking cancer nanotheranostics
Advances in nanoparticle synthesis and engineering have produced nanoscale agents
affording both therapeutic and diagnostic functions that are often referred to by the …
affording both therapeutic and diagnostic functions that are often referred to by the …
Lipid nanoparticle technology for therapeutic gene regulation in the liver
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …
people around the globe and are a major public health burden. Most contemporary …
Aptamer-based targeted therapy
Precision medicine holds great promise to harness genetic and epigenetic cues for targeted
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …
Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling
H Zhang, X You, X Wang, L Cui, Z Wang, F Xu… - Proceedings of the …, 2021 - pnas.org
Intracellular delivery of messenger RNA (mRNA)-based cancer vaccine has shown great
potential to elicit antitumor immunity. To achieve robust antitumor efficacy, mRNA encoding …
potential to elicit antitumor immunity. To achieve robust antitumor efficacy, mRNA encoding …
Non-viral vectors for gene-based therapy
Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …
Delivery materials for siRNA therapeutics
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …
To achieve the clinical potential of RNAi, delivery materials are required to transport short …
Managing diabetes with nanomedicine: challenges and opportunities
Nanotechnology-based approaches hold substantial potential for improving the care of
patients with diabetes. Nanoparticles are being developed as imaging contrast agents to …
patients with diabetes. Nanoparticles are being developed as imaging contrast agents to …
Efficient nanovaccine delivery in cancer immunotherapy
Vaccines hold tremendous potential for cancer immunotherapy by treating the immune
system. Subunit vaccines, including molecular adjuvants and cancer-associated antigens or …
system. Subunit vaccines, including molecular adjuvants and cancer-associated antigens or …
Drug delivery systems, CNS protection, and the blood brain barrier
RK Upadhyay - BioMed research international, 2014 - Wiley Online Library
Present review highlights various drug delivery systems used for delivery of pharmaceutical
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …