Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

M Jeong, Y Lee, J Park, H Jung, H Lee - Advanced drug delivery reviews, 2023 - Elsevier
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

Rethinking cancer nanotheranostics

H Chen, W Zhang, G Zhu, J **e, X Chen - Nature reviews materials, 2017 - nature.com
Advances in nanoparticle synthesis and engineering have produced nanoscale agents
affording both therapeutic and diagnostic functions that are often referred to by the …

Lipid nanoparticle technology for therapeutic gene regulation in the liver

D Witzigmann, JA Kulkarni, J Leung, S Chen… - Advanced drug delivery …, 2020 - Elsevier
Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …

Aptamer-based targeted therapy

G Zhu, X Chen - Advanced drug delivery reviews, 2018 - Elsevier
Precision medicine holds great promise to harness genetic and epigenetic cues for targeted
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …

Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling

H Zhang, X You, X Wang, L Cui, Z Wang, F Xu… - Proceedings of the …, 2021 - pnas.org
Intracellular delivery of messenger RNA (mRNA)-based cancer vaccine has shown great
potential to elicit antitumor immunity. To achieve robust antitumor efficacy, mRNA encoding …

Non-viral vectors for gene-based therapy

H Yin, RL Kanasty, AA Eltoukhy, AJ Vegas… - Nature reviews …, 2014 - nature.com
Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …

Delivery materials for siRNA therapeutics

R Kanasty, JR Dorkin, A Vegas, D Anderson - Nature materials, 2013 - nature.com
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …

Managing diabetes with nanomedicine: challenges and opportunities

O Veiseh, BC Tang, KA Whitehead… - Nature Reviews Drug …, 2015 - nature.com
Nanotechnology-based approaches hold substantial potential for improving the care of
patients with diabetes. Nanoparticles are being developed as imaging contrast agents to …

Efficient nanovaccine delivery in cancer immunotherapy

G Zhu, F Zhang, Q Ni, G Niu, X Chen - ACS nano, 2017 - ACS Publications
Vaccines hold tremendous potential for cancer immunotherapy by treating the immune
system. Subunit vaccines, including molecular adjuvants and cancer-associated antigens or …

Drug delivery systems, CNS protection, and the blood brain barrier

RK Upadhyay - BioMed research international, 2014 - Wiley Online Library
Present review highlights various drug delivery systems used for delivery of pharmaceutical
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …