GABAA receptors: structure, function, pharmacology, and related disorders
Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
GABAA receptors and the diversity in their structure and pharmacology
Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
physiological and therapeutic significance. In the brain, these pentameric receptors occur …
Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4+ T cell metabolic rewiring
Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …
disease and cancer. Here, we assess the response of immune cells to lactate in the context …
Structural insights into opposing actions of neurosteroids on GABAA receptors
Abstract γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in
the brain and are targets of numerous drugs and endogenous neurosteroids. A subset of …
the brain and are targets of numerous drugs and endogenous neurosteroids. A subset of …
Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites
Abstract γ-Aminobutyric acid receptors (GABAARs) are vital for controlling excitability in the
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …
Structural basis for GABAA receptor potentiation by neurosteroids
Type A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of inhibitory
neurotransmission in the human brain. Endogenous neurosteroids interact with GABAARs to …
neurotransmission in the human brain. Endogenous neurosteroids interact with GABAARs to …
GABA receptors: pharmacological potential and pitfalls
Gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the mammalian
central nervous system, plays a key role in the regulation of neuronal transmission …
central nervous system, plays a key role in the regulation of neuronal transmission …
[HTML][HTML] Molecular mechanisms of antiseizure drug activity at GABAA receptors
LJ Greenfield Jr - Seizure, 2013 - Elsevier
Abstract The GABA A receptor (GABA AR) is a major target of antiseizure drugs (ASDs). A
variety of agents that act at GABA A Rs s are used to terminate or prevent seizures. Many act …
variety of agents that act at GABA A Rs s are used to terminate or prevent seizures. Many act …
[HTML][HTML] GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response
BG Gunn, L Cunningham, SG Mitchell… - Frontiers in …, 2015 - Elsevier
Regulation of hypothalamic–pituitary–adrenocortical (HPA) axis activity by stress is a
fundamental survival mechanism and HPA-dysfunction is implicated in psychiatric disorders …
fundamental survival mechanism and HPA-dysfunction is implicated in psychiatric disorders …
Neurosteroids, stress and depression: potential therapeutic opportunities
Neurosteroids are potent and effective neuromodulators that are synthesized from
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …