This article reviews evidence that trait impulsivity—expressed early in life as the hyperactive–
impulsive and combined presentations of attention-deficit/hyperactivity disorder (ADHD)—is …

The Neurobiology of Adolescent Drinking in Adulthood (NADIA) Consortium has focused on
the impact of adolescent binge drinking on brain development, particularly on effects that …

Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Cirrhosis is characterized by inflammation, degeneration, and fibrosis of liver tissue. Along
with being the most common cause of liver failure and liver transplant, cirrhosis is a …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Periodic episodes of excessive alcohol consumption (“binge drinking”) occur frequently
among adolescents, and early binge drinking is associated with an increased risk of alcohol …

Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …

Repeated binge-like exposure to alcohol during adolescence has been reported to perturb
prefrontal cortical development, yet the mechanisms underlying these effects are unknown …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …