Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Ammonia is thought to be a cytotoxin and its increase in the blood impairs cell function.
However, whether and how this toxin triggers cell death under pathophysiological conditions …

Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

Endo-lysosomal escape is a highly inefficient process, which is a bottleneck for intracellular
delivery of biologics, including proteins and nucleic acids. Herein, we demonstrate the …

Drug targets are specific molecules in biological tissues and body fluids that interact with
drugs. Drug target discovery is a key component of drug discovery and is essential for the …

Synuclein aggregation in neuronal cells is the primary underlying cause of
synucleinopathies. Changes in gene expression patterns, structural modifications, and …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and affects
millions of individuals globally. AD is associated with cognitive decline and memory loss that …

Endocytosis, required for the uptake of receptors and their ligands, can also introduce
pathological aggregates such as α-synuclein (α-syn) in Parkinson's Disease. We show here …