In response to the recently released 2012 KDIGO (Kidney Disease: Improving Global
Outcomes) clinical practice guideline for acute kidney injury (AKI), the National Kidney …

Abstract N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …

Background Patients with acute myocardial infarction undergoing primary angioplasty are at
high risk for contrast-medium–induced nephropathy because of hemodynamic instability, the …

WITH THE INCREASING USE OF CONTRAST MEDIA in diagnostic and interventional
procedures, nephropathy induced by contrast media has become the third leading cause of …

Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is an
iatrogenic acute kidney injury observed after intravascular administration of contrast media …

Contrast-induced nephropathy (CIN) is the third leading cause of acute kidney injury in
hospitalized patients and is associated with significant patient morbidity. The pathogenesis …

ContextContrast-induced nephropathy is associated with significant economic and clinical
consequences, including prolonged hospitalization, the requirement for dialysis, and an …

Background: N-Acetylcysteine, theophylline, and other agents have shown inconsistent
results in reducing contrast-induced nephropathy. Purpose: To determine the effect of these …

Experimental findings in vitro and in vivo illustrate enhanced hypoxia and the formation of
reactive oxygen species (ROS) within the kidney following the administration of iodinated …

Background—It remains uncertain whether acetylcysteine prevents contrast-induced acute
kidney injury. Methods and Results—We randomly assigned 2308 patients undergoing an …