The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …

Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …

Virus-like particles resemble infectious virus particles in size, shape, and molecular
composition; however, they fail to productively infect host cells. Historically, the presence of …

Influenza A virus (IAV) is a segmented negative-sense RNA virus and is the cause of major
epidemics and pandemics. The replication of IAV is complex, involving the production of …

Like all biological populations, viral populations exist as networks of genotypes connected
through mutation. Map** the topology of these networks and quantifying population …

Single-cell analyses of viral infections reveal heterogeneity that is not detected by traditional
population-level studies. This study applies drop-based microfluidics to investigate the …

An important aspect of how viruses spread and infect is the viral burst size, or the number of
new viruses produced by each infected cell. Surprisingly, this value remains poorly …

Background Microglia participate in the immune response upon central nervous system
(CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) …

There is considerable inter-individual and inter-population variability in response to viruses.
The potential of monocytes to elicit type-I interferon responses has attracted attention to their …

Human intestinal epithelial cells form a primary barrier protecting us from pathogens, yet
only limited knowledge is available about individual contribution of each cell type to …