Advanced 3D imaging and organoid bioprinting for biomedical research and therapeutic applications
Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …
closer mimicry of human physiology compared to traditional two-dimensional cell culture …
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation
Accumulating evidence demonstrates important roles for metabolism in cell fate
determination. However, it is a challenge to assess metabolism at a spatial resolution that …
determination. However, it is a challenge to assess metabolism at a spatial resolution that …
[HTML][HTML] Human organoids-on-chips for biomedical research and applications
Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs)
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …
A microfluidic platform integrating functional vascularized organoids-on-chip
The development of vascular networks in microfluidic chips is crucial for the long-term
culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or …
culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or …
[HTML][HTML] Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells
H Tsujimoto, A Hoshina, SI Mae, T Araoka… - Cell Reports, 2024 - cell.com
Recent regenerative studies using human pluripotent stem cells (hPSCs) have developed
multiple kidney-lineage cells and organoids. However, to further form functional segments of …
multiple kidney-lineage cells and organoids. However, to further form functional segments of …
Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment
G Li, R Craig-Schapiro, D Redmond, K Chen, Y Lin… - Science …, 2025 - science.org
Tissue-specific endothelial cells (ECs) are critical for the homeostasis of pancreatic islets
and most other tissues. In vitro recapitulation of islet biology and therapeutic islet …
and most other tissues. In vitro recapitulation of islet biology and therapeutic islet …
Kidney organoids: steps towards better organization and function
Kidney organoids—3D representations of kidneys made either from pluripotent or tissue
stem cells—have been available for well over a decade. Their application could confer …
stem cells—have been available for well over a decade. Their application could confer …
[HTML][HTML] Inner ear organoids: recent progress and potential applications
Y Lou, Y Liu, M Wu, G Jia, M **a, W Li - Fundamental Research, 2023 - Elsevier
The inner ear is one of the most complicated structures that harbor organs for the perception
of sound and balance, which is deep in the temporal bone and challenging to operate …
of sound and balance, which is deep in the temporal bone and challenging to operate …
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
K Peng, W **e, T Wang, Y Li… - Stem Cell Research & …, 2023 - Springer
Background Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold
huge applications for drug screening, disease modeling, and cell transplanting therapy …
huge applications for drug screening, disease modeling, and cell transplanting therapy …
RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis
N Pode-Shakked, M Slack, N Sundaram… - Nature …, 2023 - nature.com
Abstract Autosomal Recessive Renal Tubular Dysgenesis (AR-RTD) is a fatal genetic
disorder characterized by complete absence or severe depletion of proximal tubules (PT) in …
disorder characterized by complete absence or severe depletion of proximal tubules (PT) in …