The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Amyloids are highly ordered cross-β sheet protein aggregates associated with many
diseases including Alzheimer's disease, but also with biological functions such as hormone …

Background Definite diagnosis of sporadic Creutzfeldt–Jakob disease in living patients
remains a challenge. A test that detects the specific marker for Creutzfeldt–Jakob disease …

Exosomes are small membranous vesicles secreted by a number of cell types including
neurons and can be isolated from conditioned cell media or bodily fluids such as urine and …

The discovery of infectious proteins, denoted prions, was unexpected. After much debate
over the chemical basis of heredity, resolution of this issue began with the discovery that …

Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases
following silent incubation periods that can span a lifetime. These diseases can arise …

A major problem for the effective diagnosis and management of prion diseases is the lack of
rapid high-throughput assays to measure low levels of prions. Such measurements have …

The prion hypothesis posits that a misfolded form of prion protein (PrP) is responsible for the
infectivity of prion disease. Using recombinant murine PrP purified from Escherichia coli, we …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Biomolecular condensation via liquid–liquid phase separation of intrinsically disordered
proteins/regions (IDPs/IDRs) along with other biomolecules is proposed to control critical …