Clathrin-mediated endocytosis enables selective uptake of molecules into cells in response
to changing cellular needs. It occurs through assembly of coat components around the …

Clathrin-mediated endocytosis (CME) is the primary mechanism eukaryotic cells use to
internalize material. New imaging tools are revealing the nanoscale structural dynamics of …

Protein synthesis in eukaryotes is controlled by signals and stresses via a common pathway,
called the integrated stress response (ISR). Phosphorylation of the translation initiation …

Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …

Clathrin forms diverse lattice and cage structures that change size and shape rapidly in
response to the needs of eukaryotic cells during clathrin-mediated endocytosis and …

Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also
participates to a diverse range of cellular functions. Key to this is clathrin's ability to …

Signaling receptors are internalized and regulated by clathrin-mediated endocytosis (CME).
Two clathrin light chain isoforms, CLCa and CLCb, are integral components of the endocytic …

Clathrin light chains (CLCs) control selective uptake of a range of G protein–coupled
receptors (GPCRs), although the mechanism by which this occurs has remained elusive …

Clathrins are cytoplasmic proteins that play essential roles in endocytosis and other
membrane traffic pathways. Upon recruitment to intracellular membranes, the canonical …

Adult tissue homeostasis is maintained by residential stem cells. The proliferation and
differentiation of adult stem cells must be tightly balanced to avoid excessive proliferation or …