Schistosomiasis morbidity hotspots: roles of the human host, the parasite and their interface in the development of severe morbidity

PA Mawa, J Kincaid-Smith, EM Tukahebwa… - Frontiers in …, 2021 - frontiersin.org
Schistosomiasis is the second most important human parasitic disease in terms of
socioeconomic impact, causing great morbidity and mortality, predominantly across the …

Susceptibility or resistance of praziquantel in human schistosomiasis: a review

W Wang, L Wang, YS Liang - Parasitology research, 2012 - Springer
Since praziquantel was developed in 1970s, it has replaced other antischistosomal drugs to
become the only drug of choice for treatment of human schistosomiases, due to high …

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

CM Adema, LDW Hillier, CS Jones, ES Loker… - Nature …, 2017 - nature.com
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma
mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …

Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

R Bergquist, J Utzinger, J Keiser - Infectious diseases of poverty, 2017 - Springer
The current approach of morbidity control of schistosomiasis, a helminth disease of poverty
with considerable public health and socioeconomic impact, is based on preventive …

Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution

J Utzinger, G Raso, S Brooker, D De Savigny… - Parasitology, 2009 - cambridge.org
In May 2001, the World Health Assembly (WHA) passed a resolution which urged member
states to attain, by 2010, a minimum target of regularly administering anthelminthic drugs to …

Hybridizations within the genus Schistosoma: implications for evolution, epidemiology and control

E Leger, JP Webster - Parasitology, 2017 - cambridge.org
Hybridization of parasites is an emerging public health concern in our changing world.
Hybridization and introgression in parasites and pathogens can have major impacts on the …

[HTML][HTML] From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis

J Utzinger, EK N'Goran, CR Caffrey, J Keiser - Acta tropica, 2011 - Elsevier
Compared to malaria, tuberculosis and HIV/AIDS, schistosomiasis remains a truly neglected
tropical disease. Schistosomiasis, perhaps more than any other disease, is entrenched in …

Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas

EA Ochodo, G Gopalakrishna, B Spek… - Cochrane Database …, 2015 - cochranelibrary.com
Background Point‐of‐care (POC) tests for diagnosing schistosomiasis include tests based
on circulating antigen detection and urine reagent strip tests. If they had sufficient diagnostic …

A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes

JS McCarthy, S Lustigman, GJ Yang… - PLoS neglected …, 2012 - journals.plos.org
Diagnostic tools appropriate for undertaking interventions to control helminth infections are
key to their success. Many diagnostic tests for helminth infection have unsatisfactory …

Genome-wide approaches to investigate anthelmintic resistance

SR Doyle, JA Cotton - Trends in parasitology, 2019 - cell.com
The rapid evolution of anthelmintic resistance in a number of parasites of livestock and
domesticated animals has occurred in response to widespread use of anthelmintics for …