Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management

S Dinić, J Arambašić Jovanović, A Uskoković… - Frontiers in …, 2022 - frontiersin.org
The biggest drawback of a current diabetes therapy is the treatment of the consequences not
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …

Diabetic kidney disease

MC Thomas, M Brownlee, K Susztak… - Nature reviews Disease …, 2015 - nature.com
The kidney is arguably the most important target of microvascular damage in diabetes. A
substantial proportion of individuals with diabetes will develop kidney disease owing to their …

[HTML][HTML] Treatment of diabetic kidney disease: current and future

T Yamazaki, I Mimura, T Tanaka… - … & metabolism journal, 2021 - synapse.koreamed.org
Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However,
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …

Diabetic macular edema: pathophysiology and novel therapeutic targets

A Das, PG McGuire, S Rangasamy - Ophthalmology, 2015 - Elsevier
Diabetic macular edema (DME) is the major cause of vision loss in diabetic persons.
Alteration of the blood–retinal barrier is the hallmark of this disease, characterized by …

Obesity in type 1 diabetes: pathophysiology, clinical impact, and mechanisms

KD Corbin, KA Driscoll, RE Pratley, SR Smith… - Endocrine …, 2018 - academic.oup.com
There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

Epigenetic mechanisms in diabetic complications and metabolic memory

MA Reddy, E Zhang, R Natarajan - Diabetologia, 2015 - Springer
The incidence of diabetes and its associated micro-and macrovascular complications is
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …

Biomarkers in diabetic retinopathy

AJ Jenkins, MV Joglekar, AA Hardikar… - The review of …, 2015 - pmc.ncbi.nlm.nih.gov
There is a global diabetes epidemic correlating with an increase in obesity. This coincidence
may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained …

The next generation of therapeutics for chronic kidney disease

MD Breyer, K Susztak - Nature reviews Drug discovery, 2016 - nature.com
Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …

Wound chronicity, impaired immunity and infection in diabetic patients

N Rodríguez-Rodríguez, I Martínez-Jiménez… - MEDICC …, 2022 - SciELO Public Health
BACKGROUND Diabetic foot ulcers are a common diabetic complication leading to
alarming figures of amputation, disability, and early mortality. The diabetic glucooxidative …