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Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …
complication of diabetes mellitus, are influenced by both genetic and environmental factors …
Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management
S Dinić, J Arambašić Jovanović, A Uskoković… - Frontiers in …, 2022 - frontiersin.org
The biggest drawback of a current diabetes therapy is the treatment of the consequences not
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …
Diabetic kidney disease
The kidney is arguably the most important target of microvascular damage in diabetes. A
substantial proportion of individuals with diabetes will develop kidney disease owing to their …
substantial proportion of individuals with diabetes will develop kidney disease owing to their …
[HTML][HTML] Treatment of diabetic kidney disease: current and future
T Yamazaki, I Mimura, T Tanaka… - … & metabolism journal, 2021 - synapse.koreamed.org
Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However,
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …
Diabetic macular edema: pathophysiology and novel therapeutic targets
Diabetic macular edema (DME) is the major cause of vision loss in diabetic persons.
Alteration of the blood–retinal barrier is the hallmark of this disease, characterized by …
Alteration of the blood–retinal barrier is the hallmark of this disease, characterized by …
Obesity in type 1 diabetes: pathophysiology, clinical impact, and mechanisms
There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …
diabetes in recent years. Although obesity has long been recognized as a major risk factor …
Epigenetic mechanisms in diabetic complications and metabolic memory
MA Reddy, E Zhang, R Natarajan - Diabetologia, 2015 - Springer
The incidence of diabetes and its associated micro-and macrovascular complications is
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …
Biomarkers in diabetic retinopathy
There is a global diabetes epidemic correlating with an increase in obesity. This coincidence
may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained …
may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained …
The next generation of therapeutics for chronic kidney disease
Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …
There is no cure for this disease, with current treatment strategies relying on blood pressure …
Wound chronicity, impaired immunity and infection in diabetic patients
N Rodríguez-Rodríguez, I Martínez-Jiménez… - MEDICC …, 2022 - SciELO Public Health
BACKGROUND Diabetic foot ulcers are a common diabetic complication leading to
alarming figures of amputation, disability, and early mortality. The diabetic glucooxidative …
alarming figures of amputation, disability, and early mortality. The diabetic glucooxidative …