Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide and is often associated with aspects of metabolic syndrome. Despite its …
worldwide and is often associated with aspects of metabolic syndrome. Despite its …
Lipid and Carbohydrate Metabolism in Caenorhabditis elegans
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …
An atlas of genetic influences on human blood metabolites
Genome-wide association scans with high-throughput metabolic profiling provide
unprecedented insights into how genetic variation influences metabolism and complex …
unprecedented insights into how genetic variation influences metabolism and complex …
LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis
LPCAT3 is an integral membrane acyltransferase in the Lands cycle responsible for
generating C20: 4 phospholipids and has been implicated in key biological processes such …
generating C20: 4 phospholipids and has been implicated in key biological processes such …
MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis
Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer.
Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those …
Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those …
Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
Cellular membranes are composed of numerous kinds of glycerophospholipids with different
combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 …
combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 …
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity
The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
Acyl-CoA: lysophospholipid acyltransferases
Cell membranes contain several classes of glycerophospholipids, which have numerous
structural and functional roles in the cells. Polyunsaturated fatty acids, including arachidonic …
structural and functional roles in the cells. Polyunsaturated fatty acids, including arachidonic …
New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease
VB O'Donnell - Biochemical Society Transactions, 2022 - portlandpress.com
The Lands Pathway is a fundamental biochemical process named for its discovery by
William EM Lands and revealed in a series of seminal papers published in the Journal of …
William EM Lands and revealed in a series of seminal papers published in the Journal of …
Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well
understood. Here we show that, although naive T cells are rich in polyunsaturated …
understood. Here we show that, although naive T cells are rich in polyunsaturated …