Adipose-tissue plasticity in health and disease
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
Molecular mechanisms and physiological functions of mitophagy
Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …
[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …
several types of adipose tissue have been identified, namely white, brown, and beige, that …
Adipogenesis and metabolic health
AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
Adapting to obesity with adipose tissue inflammation
Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …
senses nutrient status and regulates energy mobilization. An overall positive energy balance …
Signals from the gut microbiota to distant organs in physiology and disease
BO Schroeder, F Bäckhed - Nature medicine, 2016 - nature.com
The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is
fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived …
fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived …
The cellular and functional complexity of thermogenic fat
P Cohen, S Kajimura - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …
in the form of heat. These thermogenic fat cells were originally considered to function solely …
Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions
Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and
immunosuppressive therapeutics in the 1940s and their continued use and development …
immunosuppressive therapeutics in the 1940s and their continued use and development …
[HTML][HTML] Metabolism disrupting chemicals and metabolic disorders
The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …
disorders and metabolic syndrome have largely been attributed to genetic background and …
New advances in adaptive thermogenesis: UCP1 and beyond
Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …