Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Mitochondria form dynamic networks in the cell that are balanced by the flux of iterative
fusion and fission events of the organelles. It is now appreciated that mitochondrial fission …

Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

A common theme across multiple successful immunotherapies for cancer is the recognition
of tumor-specific mutations (neoantigens) by T cells. The rapid discovery of such antigen …

CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon
tumor antigen stimulation, and then differentiate into functional cells and migrate towards the …

Cancer cells adapt to increasing energy and biosynthetic demands by reprogramming their
metabolic pathways. Mitochondria are important organelles for the metabolic …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
conditions triggered by multiple intra-and extra-pulmonary injury factors, characterized by …

Pyruvate metabolism, a key pathway in glycolysis and oxidative phosphorylation, is crucial
for energy homeostasis and mitochondrial quality control (MQC), including fusion/fission …

Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy,
and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an …