Interferon-inducible effector mechanisms in cell-autonomous immunity

JD MacMicking - Nature Reviews Immunology, 2012 - nature.com
Interferons (IFNs) induce the expression of hundreds of genes as part of an elaborate
antimicrobial programme designed to combat infection in all nucleated cells—a process …

malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease

PD Crompton, J Moebius, S Portugal… - Annual review of …, 2014 - annualreviews.org
Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Tick immune system: what is known, the interconnections, the gaps, and the challenges

AC Fogaça, G Sousa, DB Pavanelo, E Esteves… - Frontiers in …, 2021 - frontiersin.org
Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

Mosquito innate immunity

A Kumar, P Srivastava, P Sirisena, SK Dubey, R Kumar… - Insects, 2018 - mdpi.com
Mosquitoes live under the endless threat of infections from different kinds of pathogens such
as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical …

Interaction of the tick immune system with transmitted pathogens

O Hajdušek, R Šíma, N Ayllón, M Jalovecká… - Frontiers in cellular …, 2013 - frontiersin.org
Ticks are hematophagous arachnids transmitting a wide variety of pathogens including
viruses, bacteria, and protozoans to their vertebrate hosts. The tick vector competence has to …

The Plasmodium bottleneck: malaria parasite losses in the mosquito vector

RC Smith, J Vega-Rodríguez… - Memórias do Instituto …, 2014 - SciELO Brasil
Nearly one million people are killed every year by the malaria parasite Plasmodium.
Although the disease-causing forms of the parasite exist only in the human blood …

Mosquito trilogy: microbiota, immunity and pathogens, and their implications for the control of disease transmission

P Gabrieli, S Caccia, I Varotto-Boccazzi… - Frontiers in …, 2021 - frontiersin.org
In mosquitoes, the interaction between the gut microbiota, the immune system, and the
pathogens that these insects transmit to humans and animals is regarded as a key …

A Gut Symbiotic Bacterium Serratia marcescens Renders Mosquito Resistance to Plasmodium Infection Through Activation of Mosquito Immune Responses

L Bai, L Wang, J Vega-Rodríguez, G Wang… - Frontiers in …, 2019 - frontiersin.org
The malaria development in the mosquito midgut is a complex process that results in
considerable parasite losses. The mosquito gut microbiota influences the outcome of …

Mosquito cellular immunity at single-cell resolution

G Raddi, ABF Barletta, M Efremova, JL Ramirez… - Science, 2020 - science.org
Hemocytes limit the capacity of mosquitoes to transmit human pathogens. Here we profile
the transcriptomes of 8506 hemocytes of Anopheles gambiae and Aedes aegypti mosquito …