Imaging extracellular vesicles: current and emerging methods

STY Chuo, JCY Chien, CPK Lai - Journal of biomedical science, 2018 - Springer
Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They
range from 30 nm to several micrometers in diameter, and ferry biological cargos such as …

Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era

MD Bartholoma, AS Louie, JF Valliant… - Chemical …, 2010 - ACS Publications
The objective of medical imaging using molecular probes and perfusion radiotracers is to
provide rapid, noninvasive evaluation of physiology, pathology, and/or organ function. The …

Current use and future potential of organometallic radiopharmaceuticals

R Schibli, AP Schubiger - European journal of nuclear medicine and …, 2002 - Springer
Contrary to common belief, organometallic compounds exhibit remarkable stability in
aerobic and even diluted aqueous solutions. Technetium-sestamibi (Cardiolite) is one of the …

“Click to chelate”: synthesis and installation of metal chelates into biomolecules in a single step

TL Mindt, H Struthers, L Brans, T Anguelov… - Journal of the …, 2006 - ACS Publications
Click chemistry has been employed for the assembly of novel and efficient triazole-based
multidentate chelating systems while simultaneously attaching them to molecules of …

Influence of the Denticity of Ligand Systems on the in Vitro and in Vivo Behavior of 99mTc(I)−Tricarbonyl Complexes:  A Hint for the Future Functionalization of …

R Schibli, R La Bella, R Alberto… - Bioconjugate …, 2000 - ACS Publications
Functionalization of biologically relevant molecules for the labeling with the novel fac-
[99mTc (OH2) 3 (CO) 3]+ precursor has gained considerable attention recently. Therefore …

Recent progress in fluorine-18 labelled peptide radiopharmaceuticals

S Okarvi - European journal of nuclear medicine, 2001 - Springer
The application of biologically active peptides labelled with positron-emitting nuclides has
emerged as a useful and interesting field in nuclear medicine. Small synthetic receptor …

Radiolabeling of Extracellular Vesicles with 99mTc for Quantitative In Vivo Imaging Studies

Z Varga, I Gyurkó, K Pálóczi, EI Buzás… - Cancer Biotherapy …, 2016 - liebertpub.com
The biodistribution of extracellular vesicles (EVs) is a fundamental question in the field of
circulating biomarkers, which has recently gained attention. Despite the capabilities of …

Fluorescent, phosphorescent, magnetic resonance contrast and radioactive tracer labelling of extracellular vesicles

K Wardhani, A Levina, GER Grau, PA Lay - Chemical Society Reviews, 2024 - pubs.rsc.org
This review focusses on the significance of fluorescent, phosphorescent labelling and
tracking of extracellular vesicles (EVs) for unravelling their biology, pathophysiology, and …

High‐resolution SPECT imaging of stimuli‐responsive soft microrobots

V Iacovacci, A Blanc, H Huang, L Ricotti, R Schibli… - Small, 2019 - Wiley Online Library
Untethered small‐scale robots have great potential for biomedical applications. However,
critical barriers to effective translation of these miniaturized machines into clinical practice …

New directions in the coordination chemistry of 99mTc: a reflection on technetium core structures and a strategy for new chelate design

SR Banerjee, KP Maresca, L Francesconi… - Nuclear medicine and …, 2005 - Elsevier
Bifunctional chelates offer a general approach for the linking of radioactive metal cations to
macromolecules. In the specific case of 99mTc, a variety of technologies have been …