Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective

MF Dogan, O Yildiz, SO Arslan… - Fundamental & clinical …, 2019 - Wiley Online Library
Potassium (K+) ion channel activity is an important determinant of vascular tone by
regulating cell membrane potential (MP). Activation of K+ channels leads to membrane …

Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart

A Saint‐Martin Willer, J Santos‐Gomes… - The Journal of …, 2023 - Wiley Online Library
Potassium channel subfamily K member 3 (KCNK3), encoded by the KCNK3 gene, is part of
the two‐pore domain potassium channel family, constitutively active at resting membrane …

Targeting two‐pore domain K+ channels TREK‐1 and TASK‐3 for the treatment of depression: a new therapeutic concept

M Borsotto, J Veyssiere… - British journal of …, 2015 - Wiley Online Library
Depression is a disease that is particularly frequent, affecting up to 20% of the population in
W estern countries. The origins of this pathology involve multiple genes as well as …

Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations

SK Ganesh, DI Chasman, MG Larson, X Guo… - The American Journal of …, 2014 - cell.com
Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and
susceptibility to measurement error. Genetic studies of BP generally use single-visit …

The role of K2P channels in anaesthesia and sleep

EA Steinberg, KA Wafford, SG Brickley… - … -European Journal of …, 2015 - Springer
Tandem two-pore potassium channels (K 2P s) have widespread expression in the central
nervous system and periphery where they contribute to background membrane …

Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex

N Decher, K Wemhöner, S Rinné, MF Netter… - Cellular Physiology and …, 2011 - karger.com
Abstract Background/Aims: The aim of the study was to characterize the whole cell current of
the two-pore domain potassium channel TASK-1 (K2P3) in mouse ventricular …

From the background to the spotlight: TASK channels in pathological conditions

S Bittner, T Budde, H Wiendl, SG Meuth - Brain Pathology, 2010 - Wiley Online Library
TWIK‐related acid‐sensitive potassium channels (TASK1–3) belong to the family of two‐
pore domain (K2P) potassium channels. Emerging knowledge about an involvement of …

Genome-wide association study meta-analysis of long-term average blood pressure in East Asians

C Li, YK Kim, R Dorajoo, H Li, IT Lee… - Circulation …, 2017 - Am Heart Assoc
Background—Genome-wide single marker and gene-based meta-analyses of long-term
average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP. Methods …

White matter is the predilection site of late-delayed radiation-induced brain injury in non-human primates

RN Andrews, GO Dugan, AM Peiffer… - Radiation …, 2019 - meridian.allenpress.com
Fractionated whole-brain irradiation for the treatment of intracranial neoplasia causes
progressive neurodegeneration and neuroinflammation. The long-term consequences of …

Research into the therapeutic roles of two-pore-domain potassium channels

Z Es-Salah-Lamoureux, DF Steele, D Fedida - Trends in pharmacological …, 2010 - cell.com
The K 2P potassium channels are responsible for the background conductance observed in
several tissues. Their ubiquitous localization and thus their potential implications in diseases …