Detergents are widely used for membrane protein solubilization, purification, and structural
analysis. Over the past two decades, much effort has been made to design novel detergents …

Whereas membrane proteins make up∼ 23% of the human proteome, it is estimated that
membrane proteins constitute more than 60% of current drug targets. With membrane …

Maintaining protein stability in an aqueous solution is a prerequisite for protein structural
and functional studies, but conventional detergents have increasingly showed limited ability …

Membrane protein structures provide atomic level insight into essential biochemical
processes and facilitate protein structure-based drug design. However, the inherent …

Detergents are amphiphilic molecules that serve as enabling steps for today's world
applications. The increasing diversity of the detergentome is key to applications enabled by …

Highlights•Membrane proteins (MPs) are challenging for structural studies.•Stabilization of
MPs outside their native environment is non-trivial.•Detergents, lipids, polymers, scaffold …

Membrane proteins are widely studied in detergent micelles, a membrane-mimetic system
formed by amphiphilic compounds. However, classical detergents have serious limitations in …

Glucoside detergents are successfully used for membrane protein crystallization mainly
because of their ability to form small protein-detergent complexes. In a previous study, we …

Detergents are widely used to isolate membrane proteins from lipid bilayers, but many
proteins solubilized in conventional detergents are structurally unstable. Thus, there is major …

Despite their major biological and pharmacological significance, the structural and
functional study of membrane proteins remains a significant challenge. A main issue is the …