The Role of Platelets in Atherosclerosis: A Historical Review

S Momi, P Gresele - Seminars in Thrombosis and Hemostasis, 2024 - thieme-connect.com
Atherosclerosis is a chronic, multifactorial inflammatory disorder of large and medium-size
arteries, which is the leading cause of cardiovascular mortality and morbidity worldwide …

[HTML][HTML] MITOCDNB DECREASES PLATELET ACTIVATION THROUGH ITS SELECTIVE ACTION ON MITOCHONDRIAL THIOREDOXIN REDUCTASE

D Méndez, F Tellería, M Alarcón… - Biomedicine & …, 2025 - Elsevier
Platelet inhibition is a fundamental objective to prevent and treat thrombus formation.
Platelet activation depends on mitochondrial function. This study aims to identify a new …

IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis

B Xu, X Ye, K Sun, L Chen, Z Wen, Q Lan… - Advanced …, 2025 - Wiley Online Library
Platelets play crucial roles in multiple pathophysiological processes after energy‐dependent
activation. It is puzzling how such a small cellular debris has abundant energy supply. In this …

PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer

J Li, J Liu, S Yang, Y **a, Q Meng, B Sun, Y Liu… - Cell Communication and …, 2025 - Springer
Background Programmed cell death ligand 1 (PD-L1) expression on immune cells is
correlated with the efficacy of immune checkpoint inhibitor (ICI) therapy in various types of …

A tight interplay between platelet activation and mitochondrial DNA release promotes platelet storage lesion in platelet concentrates

K Haeri, S Samiee, P Beigi, S Hajati… - Vox Sanguinis, 2024 - Wiley Online Library
Abstract Background and Objectives Platelet storage lesion (PSL) adversely affects the
quality of platelet concentrates (PCs). Platelets are prone to activation during storage …

Small but mighty: Platelets as multifunctional architects of tumor metastasis and immune regulation

L Tang, H Shi, Y Luo - MedComm–Future Medicine, 2024 - Wiley Online Library
Platelets play an irreplaceable role in hemostasis and wound healing. However, beyond
these classical roles, as the smallest anucleate cells in the blood stream, they are crucial for …

New Dimension to Study on Platelet Bioenergetics

D Dash - Arteriosclerosis, Thrombosis, and Vascular Biology, 2024 - ahajournals.org
Within their limited life span (10–12 days in humans and 4–5 days in mice), platelets
traverse through the alleys and sub-alleys of blood vessels with an onerous mandate to …

Perspective Diagnostic Marker of Mitochondrial Bioenergetics

Z Sumbalová - Translational Mitochondrial Medicine, 2024 - Springer
Mitochondria are part of almost every eukaryotic cell, they carry out nutrient metabolism and
energy production in the process of oxidative phosphorylation. Mitochondria are involved in …

Transferencia mitocondrial artificial de plaquetas en osteoartritis: evaluación in vitro de su potencial terapéutico en condrocitos derivados de pacientes

NA Jeraldo Araya - 2024 - repositorio.uchile.cl
La osteoartritis (OA) es una enfermedad articular crónica y progresiva caracterizada por
dolor, inflamación y rigidez en el movimiento, cuya incidencia y prevalencia han aumentado …