Scientific discovery in the age of artificial intelligence

H Wang, T Fu, Y Du, W Gao, K Huang, Z Liu… - Nature, 2023‏ - nature.com
Artificial intelligence (AI) is being increasingly integrated into scientific discovery to augment
and accelerate research, hel** scientists to generate hypotheses, design experiments …

Cell-free gene expression

D Garenne, MC Haines, EF Romantseva… - Nature reviews …, 2021‏ - nature.com
Cell-free gene expression (CFE) emerged as an alternative approach to living cells for
specific applications in protein synthesis and labelling for structural biology and proteomics …

Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism

J Zhang, SD Petersen, T Radivojevic, A Ramirez… - Nature …, 2020‏ - nature.com
Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …

[HTML][HTML] Advanced machine-learning techniques in drug discovery

M Elbadawi, S Gaisford, AW Basit - Drug Discovery Today, 2021‏ - Elsevier
Highlights•Machine learning techniques (MLTs) are progressing the drug discovery
process.•Conventional MLTs require large data, lack transparency and are not …

A versatile active learning workflow for optimization of genetic and metabolic networks

A Pandi, C Diehl, A Yazdizadeh Kharrazi… - Nature …, 2022‏ - nature.com
Optimization of biological networks is often limited by wet lab labor and cost, and the lack of
convenient computational tools. Here, we describe METIS, a versatile active machine …

Recent advances in machine learning applications in metabolic engineering

P Patra, BR Disha, P Kundu, M Das, A Ghosh - Biotechnology advances, 2023‏ - Elsevier
Metabolic engineering encompasses several widely-used strategies, which currently hold a
high seat in the field of biotechnology when its potential is manifesting through a plethora of …

[HTML][HTML] Automating the design-build-test-learn cycle towards next-generation bacterial cell factories

N Gurdo, DC Volke, D McCloskey, PI Nikel - New Biotechnology, 2023‏ - Elsevier
Automation is playing an increasingly significant role in synthetic biology. Groundbreaking
technologies, developed over the past 20 years, have enormously accelerated the …

The all-E. coliTXTL toolbox 3.0: new capabilities of a cell-free synthetic biology platform

D Garenne, S Thompson, A Brisson… - Synthetic …, 2021‏ - academic.oup.com
The new generation of cell-free gene expression systems enables the prototy** and
engineering of biological systems in vitro over a remarkable scope of applications and …

Biological research and self-driving labs in deep space supported by artificial intelligence

LM Sanders, RT Scott, JH Yang, AA Qutub… - Nature Machine …, 2023‏ - nature.com
Abstract Space biology research aims to understand fundamental spaceflight effects on
organisms, develop foundational knowledge to support deep space exploration and …

Enabling technology and core theory of synthetic biology

XE Zhang, C Liu, J Dai, Y Yuan, C Gao, Y Feng… - Science China Life …, 2023‏ - Springer
Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …