The US opioid crisis came in three waves—prescription opioids, heroin, and illicitly
manufactured fentanyls—Centers for Disease Control and Prevention Centers for Disease …

Background Sharp exacerbations of the US overdose crisis are linked to polysubstance use
of synthetic compounds. Xylazine is a veterinary tranquilizer, long noted in the street opioid …

Background Overdose deaths from synthetic opioids (eg, fentanyl) increased 10-fold in the
United States from 2013 to 2018, despite such opioids being rare in illicit drug markets west …

Background Amidst an increasingly toxic drug supply in North America, people who inject
drugs may be transitioning to smoking them. We aimed to assess changes in injecting and …

Synthetic opioids have played a significant role in the current opioid crisis in the United
States (US) and Canada and are a matter of concern worldwide. New psychoactive opioids …

North America has been contending with an unregulated street drug supply in which opioids
are often adulterated with illicitly manufactured fentanyl. The unpredictability of composition …

Background Fentanyl-and methamphetamine-based counterfeit prescription drugs have
driven escalating overdose death rates in the US, however their presence in Mexico has not …

Background The coronavirus disease 2019 (COVID-19) pandemic is co-occurring with a
drug addiction and overdose crisis. Methods We fit overdispersed Poisson models …

Background Smoking or inhaling illicit drugs can lead to a variety of negative health
outcomes, including overdose. However, most overdose prevention interventions, such as …

Background Perception of drug adulteration has increased in Mexico, but there is little
research on adulterants and toxicity. The aim of this study was to identify drug composition in …