Antimalarial activity of plant metabolites
WH Pan, XY Xu, N Shi, SW Tsang… - International Journal of …, 2018 - mdpi.com
Malaria, as a major global health problem, continues to affect a large number of people each
year, especially those in develo** countries. Effective drug discovery is still one of the …
year, especially those in develo** countries. Effective drug discovery is still one of the …
The genus Jatropha (Euphorbiaceae): A review on secondary chemical metabolites and biological aspects
NB Cavalcante, AD da Conceição Santos… - Chemico-biological …, 2020 - Elsevier
The genus Jatropha belongs to the Euphorbiaceae family and has about 175 species.
Originally from tropical America, the Jatropha genus can be found all over the tropics and …
Originally from tropical America, the Jatropha genus can be found all over the tropics and …
Production of bioactive diterpenoids in the Euphorbiaceae depends on evolutionarily conserved gene clusters
The Euphorbiaceae produce a diverse range of diterpenoids, many of which have
pharmacological activities. These diterpenoids include ingenol mebutate, which is licensed …
pharmacological activities. These diterpenoids include ingenol mebutate, which is licensed …
Plants as antimalarial agents in Sub-Saharan Africa
KC Chinsembu - Acta tropica, 2015 - Elsevier
Although the burden of malaria is decreasing, parasite resistance to current antimalarial
drugs and resistance to insecticides by vector mosquitoes threaten the prospects of malaria …
drugs and resistance to insecticides by vector mosquitoes threaten the prospects of malaria …
The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer
Metastatic breast cancer is the leading cause of worldwide cancer-related deaths among
women. Triple negative breast cancers (TNBC) are highly metastatic and are devoid of …
women. Triple negative breast cancers (TNBC) are highly metastatic and are devoid of …
New dimensions in the field of antimalarial research against malaria resurgence
Malaria is a life threatening disease caused by microscopic parasites called Plasmodium
that are transmitted to human beings by mosquitoes. Single celled Eukaryotic plasmodium …
that are transmitted to human beings by mosquitoes. Single celled Eukaryotic plasmodium …
Early preclinical studies of ergosterol peroxide and biological evaluation of its derivatives
T Ling, LV Arroyo-Cruz, WR Smither, EK Seighman… - ACS …, 2024 - ACS Publications
Ganoderma lucidum is a medicinal mushroom that produces various pharmacological
compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol …
compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol …
Antimalarial activity of abietane ferruginol analogues possessing a phthalimide group
Abstract The abietane-type diterpenoid (+)-ferruginol, a bioactive compound isolated from
New Zealand's Miro tree (Podocarpus ferruginea), displays relevant pharmacological …
New Zealand's Miro tree (Podocarpus ferruginea), displays relevant pharmacological …
Cytostatic and cytotoxic natural products against cancer cell models
T Ling, WH Lang, J Maier, M Quintana Centurion… - Molecules, 2019 - mdpi.com
The increasing prevalence of drug resistant and/or high-risk cancers indicate further drug
discovery research is required to improve patient outcome. This study outlines a simplified …
discovery research is required to improve patient outcome. This study outlines a simplified …
(+)-Dehydroabietylamine derivatives target triple-negative breast cancer
Breast cancer remains the leading cause of cancer-related death among women. The
invasive triple-negative subtype is unresponsive to estrogen therapy, and few effective …
invasive triple-negative subtype is unresponsive to estrogen therapy, and few effective …