Antimalarial activity of plant metabolites

WH Pan, XY Xu, N Shi, SW Tsang… - International Journal of …, 2018 - mdpi.com
Malaria, as a major global health problem, continues to affect a large number of people each
year, especially those in develo** countries. Effective drug discovery is still one of the …

The genus Jatropha (Euphorbiaceae): A review on secondary chemical metabolites and biological aspects

NB Cavalcante, AD da Conceição Santos… - Chemico-biological …, 2020 - Elsevier
The genus Jatropha belongs to the Euphorbiaceae family and has about 175 species.
Originally from tropical America, the Jatropha genus can be found all over the tropics and …

Production of bioactive diterpenoids in the Euphorbiaceae depends on evolutionarily conserved gene clusters

AJ King, GD Brown, AD Gilday, TR Larson… - The Plant …, 2014 - academic.oup.com
The Euphorbiaceae produce a diverse range of diterpenoids, many of which have
pharmacological activities. These diterpenoids include ingenol mebutate, which is licensed …

Plants as antimalarial agents in Sub-Saharan Africa

KC Chinsembu - Acta tropica, 2015 - Elsevier
Although the burden of malaria is decreasing, parasite resistance to current antimalarial
drugs and resistance to insecticides by vector mosquitoes threaten the prospects of malaria …

The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer

I Fatima, I El-Ayachi, L Taotao, MA Lillo, R Krutilina… - PloS one, 2017 - journals.plos.org
Metastatic breast cancer is the leading cause of worldwide cancer-related deaths among
women. Triple negative breast cancers (TNBC) are highly metastatic and are devoid of …

New dimensions in the field of antimalarial research against malaria resurgence

AK Narula, CS Azad, LM Nainwal - European Journal of Medicinal …, 2019 - Elsevier
Malaria is a life threatening disease caused by microscopic parasites called Plasmodium
that are transmitted to human beings by mosquitoes. Single celled Eukaryotic plasmodium …

Early preclinical studies of ergosterol peroxide and biological evaluation of its derivatives

T Ling, LV Arroyo-Cruz, WR Smither, EK Seighman… - ACS …, 2024 - ACS Publications
Ganoderma lucidum is a medicinal mushroom that produces various pharmacological
compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol …

Antimalarial activity of abietane ferruginol analogues possessing a phthalimide group

MA González, J Clark, M Connelly, F Rivas - Bioorganic & medicinal …, 2014 - Elsevier
Abstract The abietane-type diterpenoid (+)-ferruginol, a bioactive compound isolated from
New Zealand's Miro tree (Podocarpus ferruginea), displays relevant pharmacological …

Cytostatic and cytotoxic natural products against cancer cell models

T Ling, WH Lang, J Maier, M Quintana Centurion… - Molecules, 2019 - mdpi.com
The increasing prevalence of drug resistant and/or high-risk cancers indicate further drug
discovery research is required to improve patient outcome. This study outlines a simplified …

(+)-Dehydroabietylamine derivatives target triple-negative breast cancer

T Ling, M Tran, MA Gonzalez, LN Gautam… - European Journal of …, 2015 - Elsevier
Breast cancer remains the leading cause of cancer-related death among women. The
invasive triple-negative subtype is unresponsive to estrogen therapy, and few effective …