There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

Background Dysregulated activation of the inflammasome is involved in various human
diseases including acute cerebral ischemia, multiple sclerosis and sepsis. Though many …

Inflammation is a devastating pathophysiological process during stroke, a devastating
disease that is the second most common cause of death worldwide. Activation of the NOD …

From the global perspective, stroke refers to a highly common cause of disability and death.
Ischemic stroke (IS), attributed to blood vessel blockage, preventing the flow of blood to …

Background Recently, several studies have demonstrated that the NLRP3 inflammasome
participates in detecting cellular damage and mediating inflammatory responses to aseptic …

The search of effective anti-stroke neuroprotectors requires various stroke models adequate
for different aspects of the ischemic processes. The photothrombotic stroke model is …

Cerebral ischemia is a pathological condition resulting from the cessation or reduction of
blood supply to the cerebral arteries. Neurological deficits that are clinically relevant can …

The volume-regulated anion channel (VRAC), also known as the volume-sensitive
outwardly rectifying (VSOR) anion channel or the volume-sensitive organic osmolyte/anion …

Stroke is one of the major devastating diseases with no effective medical therapeutics.
Because of the high rate of disability and mortality among stroke patients, new treatments …