The integrated brain network that controls respiration
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …
Neurotoxins acting at synaptic sites: A brief review on mechanisms and clinical applications
Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …
Clinical Spectrum of KCNA1 Mutations: New Insights into Episodic Ataxia and Epilepsy Comorbidity
Mutations in the KCNA1 gene, which encodes voltage-gated Kv1. 1 potassium channel α-
subunits, cause a variety of human diseases, complicating simple genotype–phenotype …
subunits, cause a variety of human diseases, complicating simple genotype–phenotype …
Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors
With swee** advances in precision delivery systems and manipulation of the genomes
and transcriptomes of various cell types, medical biotechnology offers unprecedented …
and transcriptomes of various cell types, medical biotechnology offers unprecedented …
Purkinje cell signaling deficits in animal models of ataxia
Purkinje cell (PC) dysfunction or degeneration is the most frequent finding in animal models
with ataxic symptoms. Mutations affecting intrinsic membrane properties can lead to ataxia …
with ataxic symptoms. Mutations affecting intrinsic membrane properties can lead to ataxia …
LGI3/2–ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period
N Kozar-Gillan, A Velichkova, G Kanatouris… - Journal of Cell …, 2023 - rupress.org
Along myelinated axons, Shaker-type potassium channels (Kv1) accumulate at high density
in the juxtaparanodal region, directly adjacent to the paranodal axon–glia junctions that …
in the juxtaparanodal region, directly adjacent to the paranodal axon–glia junctions that …
Genetic etiologies of the electrical status epilepticus during slow wave sleep: systematic review
M Kessi, J Peng, L Yang, J **ong, H Duan, N Pang… - BMC genetics, 2018 - Springer
Background Electrical status epilepticus during slow-wave sleep (ESESS) which is also
known as continuous spike-wave of slow sleep (CSWSS) is type of electroencephalographic …
known as continuous spike-wave of slow sleep (CSWSS) is type of electroencephalographic …
Marine toxins targeting Kv1 channels: pharmacological tools and therapeutic scaffolds
Toxins from marine animals provide molecular tools for the study of many ion channels,
including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity …
including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity …
Kv1. 1 channels inhibition in the rat motor cortex recapitulates seizures associated with anti-LGI1 encephalitis
Autoimmune encephalitis associated with antibodies directed against the leucine-rich
glioma inactivated 1 (LGI1) protein is responsible for specific tonic-dystonic motor seizures …
glioma inactivated 1 (LGI1) protein is responsible for specific tonic-dystonic motor seizures …
Familial paroxysmal kinesigenic dyskinesia is associated with mutations in the KCNA1 gene
XM Yin, JH Lin, L Cao, TM Zhang, S Zeng… - Human molecular …, 2018 - academic.oup.com
Paroxysmal kinesigenic dyskinesia (PKD) is a heterogeneous movement disorder
characterized by recurrent dyskinesia attacks triggered by sudden movement. PRRT2 has …
characterized by recurrent dyskinesia attacks triggered by sudden movement. PRRT2 has …