The integrated brain network that controls respiration

F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Neurotoxins acting at synaptic sites: A brief review on mechanisms and clinical applications

K Zhou, W Luo, T Liu, Y Ni, Z Qin - Toxins, 2022 - mdpi.com
Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

Clinical Spectrum of KCNA1 Mutations: New Insights into Episodic Ataxia and Epilepsy Comorbidity

K Paulhus, L Ammerman, E Glasscock - International Journal of …, 2020 - mdpi.com
Mutations in the KCNA1 gene, which encodes voltage-gated Kv1. 1 potassium channel α-
subunits, cause a variety of human diseases, complicating simple genotype–phenotype …

Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors

SV Ovsepian, SG Waxman - Nature Reviews Neuroscience, 2023 - nature.com
With swee** advances in precision delivery systems and manipulation of the genomes
and transcriptomes of various cell types, medical biotechnology offers unprecedented …

Purkinje cell signaling deficits in animal models of ataxia

E Hoxha, I Balbo, MC Miniaci, F Tempia - Frontiers in synaptic …, 2018 - frontiersin.org
Purkinje cell (PC) dysfunction or degeneration is the most frequent finding in animal models
with ataxic symptoms. Mutations affecting intrinsic membrane properties can lead to ataxia …

LGI3/2–ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period

N Kozar-Gillan, A Velichkova, G Kanatouris… - Journal of Cell …, 2023 - rupress.org
Along myelinated axons, Shaker-type potassium channels (Kv1) accumulate at high density
in the juxtaparanodal region, directly adjacent to the paranodal axon–glia junctions that …

Genetic etiologies of the electrical status epilepticus during slow wave sleep: systematic review

M Kessi, J Peng, L Yang, J **ong, H Duan, N Pang… - BMC genetics, 2018 - Springer
Background Electrical status epilepticus during slow-wave sleep (ESESS) which is also
known as continuous spike-wave of slow sleep (CSWSS) is type of electroencephalographic …

Marine toxins targeting Kv1 channels: pharmacological tools and therapeutic scaffolds

RK Finol-Urdaneta, A Belovanovic, M Micic-Vicovac… - Marine drugs, 2020 - mdpi.com
Toxins from marine animals provide molecular tools for the study of many ion channels,
including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity …

Kv1. 1 channels inhibition in the rat motor cortex recapitulates seizures associated with anti-LGI1 encephalitis

P Baudin, S Whitmarsh, L Cousyn, D Roussel… - Progress in …, 2022 - Elsevier
Autoimmune encephalitis associated with antibodies directed against the leucine-rich
glioma inactivated 1 (LGI1) protein is responsible for specific tonic-dystonic motor seizures …

Familial paroxysmal kinesigenic dyskinesia is associated with mutations in the KCNA1 gene

XM Yin, JH Lin, L Cao, TM Zhang, S Zeng… - Human molecular …, 2018 - academic.oup.com
Paroxysmal kinesigenic dyskinesia (PKD) is a heterogeneous movement disorder
characterized by recurrent dyskinesia attacks triggered by sudden movement. PRRT2 has …