Clinical and pathophysiological understanding of septic shock has progressed exponentially
in the previous decades, translating into a steady decrease in septic shock-related morbidity …

Sepsis-induced myocardial dysfunction is increasingly recognized as a major contributor to
outcome of septic shock. Significant strides have been made in understanding the …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

As the prevalence of heart failure (HF) continues to rise, prompt diagnosis and management
of various medical conditions, which may lead to HF exacerbation and result in poor patient …

Background Treatment decisions on critically ill patients with circulatory shock lack
consensus. In an international survey, we aimed to evaluate the indications, current practice …

Sepsis is a systemic inflammatory response syndrome of suspected or documented
infectious origin, whose outcome is multiorgan failure. Sepsis-induced myocardial …

Oxygen is needed to generate aerobic adenosine triphosphate and energy that is required
to support vital cellular functions. Oxygen delivery (DO 2) to the tissues is determined by …

Levosimendan and dobutamine are extensively used to treat sepsis-associated
cardiovascular failure in ICU. Nevertheless, the role and mechanism of levosimendan in …

Objective: We conducted a systematic review to assess the advantages and disadvantages
of levosimendan in patients with sepsis compared with placebo, milrinone, and dobutamine …

Sepsis induced myocardial dysfunction (SIMD) results in high morbidity and mortality.
However, the effective therapeutic strategies for SIMD treatment remain limited. Sirt3 is the …