We did a global review to synthesise data on the prevalence, harms, and interventions for
stimulant use, focusing specifically on the use of cocaine and amphetamines. Modelling …

Opioid use disorder (OUD) is associated with a high risk of premature death. Medication-
assisted treatment (MAT) is the primary treatment for opioid dependence. We …

The sale of cannabis for adult recreational use has been made legal in nine US states since
2012, and nationally in Uruguay in 2013 and Canada in 2018. We review US research on …

Background Up-to-date evidence about levels and trends in disease and injury incidence,
prevalence, and years lived with disability (YLDs) is an essential input into global, regional …

Background. Cannabis use is common in North America, especially among young people,
and is associated with a risk of various acute and chronic adverse health outcomes …

Background The Global Burden of Disease Study 2010 (GBD 2010), estimated that a
substantial proportion of the world's disease burden came from mental, neurological and …

We assess the current and describe possible future public health impacts of the legalisation
of cannabis production, sale, and use in the Americas. First, we describe global patterns of …

Substance use in young people (aged 10–24 years) might disrupt key periods of transition
that occur as the adolescent brain undergoes cognitive and emotional development, and …

Background We used data from the Global Burden of Diseases, Injuries, and Risk Factors
Study 2010 (GBD 2010) to estimate the burden of disease attributable to mental and …

Background Alcohol use is a leading risk factor for death and disability, but its overall
association with health remains complex given the possible protective effects of moderate …