Cell migration results from stepwise mechanical and chemical interactions between cells
and their extracellular environment. Mechanistic principles that determine single-cell and …

Two major mechanisms are involved in the formation of blood vasculature: vasculogenesis
and angiogenesis. The former term describes the formation of a capillary-like network from …

In vitro cultures of endothelial cells are a widely used model system of the collective
behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an …

Human physiological functions are regulated across many orders of magnitude in space and
time. Integrating the information and dynamics from one scale to another is critical for the …

Angiogenesis, the formation of new blood vessels sprouting from existing ones, occurs in
several situations like wound healing, tissue remodeling, and near growing tumors. Under …

Endothelial cell adhesion and migration are critical steps of the angiogenic process, whose
dysfunction is associated with tumor growth and metastasis. The TRPM8 channel has …

Multiscale problems are ubiquitous and fundamental in all biological phenomena that
emerge naturally from the complex interaction of processes which occur at various levels. A …

We develop an off-lattice, agent-based model to describe vasculogenesis, the de novo
formation of blood vessels from endothelial progenitor cells during development. The …

There are numerous biological examples where genes associated with migratory ability of
cells also confer the cells with an increased fitness even though these genes may not have …

In autosomal dominant polycystic kidney disease (ADPKD), cysts accumulate and
progressively impair renal function. Mutations in PKD1 and PKD2 genes are causally linked …