What genetics tells us about the causes and mechanisms of Parkinson's disease
O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
Clinical approach to Parkinson's disease: features, diagnosis, and principles of management
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The
condition causes a heavy burden both on those affected, as well as their families. Accurate …
condition causes a heavy burden both on those affected, as well as their families. Accurate …
Impaired mitochondrial function in psychiatric disorders
Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent
mental illnesses that affect the lives of millions of individuals. Although these disorders have …
mental illnesses that affect the lives of millions of individuals. Although these disorders have …
The neuropathology of genetic Parkinson's disease
M Poulopoulos, OA Levy, RN Alcalay - Movement Disorders, 2012 - Wiley Online Library
Pathological data from autopsies genotyped for Parkinson's disease (PD)‐related mutations
in alpha‐synuclein, Parkin, PINK1, DJ1, LRRK2, and glucocerebrosidase have accumulated …
in alpha‐synuclein, Parkin, PINK1, DJ1, LRRK2, and glucocerebrosidase have accumulated …
PINK1-linked parkinsonism is associated with Lewy body pathology
Phosphatase and tensin homolog-induced putative kinase 1 gene mutations have been
associated with autosomal recessive early-onset Parkinson's disease. To date, no …
associated with autosomal recessive early-onset Parkinson's disease. To date, no …
Cognitive impairment and dementia in Parkinson's disease: clinical features, diagnosis, and management
J Meireles, J Massano - Frontiers in neurology, 2012 - frontiersin.org
Parkinson's disease (PD) is a common, disabling, neurodegenerative disorder. In addition to
classical motor symptoms, non-motor features are now widely accepted as part of the clinical …
classical motor symptoms, non-motor features are now widely accepted as part of the clinical …
Psychosis in Parkinson's disease: epidemiology, pathophysiology, and management
A Chang, SH Fox - Drugs, 2016 - Springer
Psychotic symptoms are common in Parkinson's disease (PD) and are associated with
poorer quality of life and increased caregiver burden. PD psychosis is correlated with …
poorer quality of life and increased caregiver burden. PD psychosis is correlated with …
Familial Parkinson's disease–genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease
C Schiesling, N Kieper, K Seidel… - Neuropathology and …, 2008 - Wiley Online Library
The identification of the first gene in familial Parkinson's disease (PD) only 10 years ago was
a major step in the understanding of the molecular mechanisms in neurodegeneration …
a major step in the understanding of the molecular mechanisms in neurodegeneration …
Beyond the mitochondrion: cytosolic PINK 1 remodels dendrites through Protein Kinase A
The subcellular compartmentalization of kinase activity allows for regulation of distinct
cellular processes involved in cell differentiation or survival. The PTEN‐induced kinase 1 …
cellular processes involved in cell differentiation or survival. The PTEN‐induced kinase 1 …
[HTML][HTML] Genetics of Parkinson disease
N Pankratz, T Foroud - Genetics in medicine, 2007 - Elsevier
During the past decade five genes have been identified that are important in autosomal
dominant and autosomal recessive forms of Parkinson disease. The identification of these …
dominant and autosomal recessive forms of Parkinson disease. The identification of these …