NAD+ metabolism and its roles in cellular processes during ageing
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
NAD+ homeostasis in health and disease
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
The multifaceted contributions of mitochondria to cellular metabolism
JB Spinelli, MC Haigis - Nature cell biology, 2018 - nature.com
Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …
SLC25A51 is a mammalian mitochondrial NAD+ transporter
Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the
fundamental processes that fuel respiration and mediate cellular energy transduction …
fundamental processes that fuel respiration and mediate cellular energy transduction …
Therapeutic potential of NAD-boosting molecules: the in vivo evidence
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …
well known for its role in redox reactions. More recently, it has emerged as a signaling …
NAD+ in brain aging and neurodegenerative disorders
NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability,
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …
Fasting and cancer: molecular mechanisms and clinical application
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …
[HTML][HTML] Role of NAD+ in regulating cellular and metabolic signaling pathways
Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …
every living cell, is involved in a myriad of metabolic processes associated with cellular …
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …