Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT)
are physiological processes required for normal embryogenesis. However, these processes …

Glioma is the most common primary malignant brain tumor with poor survival and limited
therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that
has been associated with several types of cancer. However, its biological significance, as …

Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

In tissues, cells reside in confining microenvironments, which may mechanically restrict the
ability of a cell to double in size as it prepares to divide. How confinement affects cell cycle …

Cancer metastasis is one of the leading causes of death worldwide, motivating research into
identifying new methods of preventing cancer metastasis. Recently there has been …

Phenotypic polarization of macrophages is deemed essential in innate immunity and various
pathophysiological conditions. We have now determined key aspects of the molecular …

In many cases, the mechanical properties of a tumor are different from those of the host
tissue. Mechanical cues regulate cancer development by affecting both tumor cells and their …