Smart nanoparticles for cancer therapy

L Sun, H Liu, Y Ye, Y Lei, R Islam, S Tan… - Signal transduction and …, 2023 - nature.com
Smart nanoparticles, which can respond to biological cues or be guided by them, are
emerging as a promising drug delivery platform for precise cancer treatment. The field of …

Polymeric nanoparticles for drug delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Engineering precision nanoparticles for drug delivery

MJ Mitchell, MM Billingsley, RM Haley… - Nature reviews drug …, 2021 - nature.com
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …

Inorganic sonosensitizers for sonodynamic therapy in cancer treatment

X Cao, M Li, Q Liu, J Zhao, X Lu, J Wang - Small, 2023 - Wiley Online Library
The rapid development of nanomedicine and nanobiotechnology has allowed the
emergence of various therapeutic modalities with excellent therapeutic efficiency and …

Understanding and targeting resistance mechanisms in cancer

ZN Lei, Q Tian, QX Teng, JND Wurpel, L Zeng… - MedComm, 2023 - Wiley Online Library
Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

Enhancing in situ cancer vaccines using delivery technologies

N Gong, MG Alameh, R El-Mayta, L Xue… - Nature Reviews Drug …, 2024 - nature.com
In situ cancer vaccination refers to any approach that exploits tumour antigens available at a
tumour site to induce tumour-specific adaptive immune responses. These approaches hold …

Extracellular matrix (ECM) stiffness and degradation as cancer drivers

M Najafi, B Farhood… - Journal of cellular …, 2019 - Wiley Online Library
Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

Free radical as a double-edged sword in disease: Deriving strategic opportunities for nanotherapeutics

L Zhu, M Luo, Y Zhang, F Fang, M Li, F An… - Coordination chemistry …, 2023 - Elsevier
Free radicals, usually containing one or more unpaired electrons, are extremely unstable
and highly reactive with other biological molecules. Recently, there has been increasing …

Self-amplification of tumor oxidative stress with degradable metallic complexes for synergistic cascade tumor therapy

G Chen, Y Yang, Q Xu, M Ling, H Lin, W Ma, R Sun… - Nano …, 2020 - ACS Publications
The ferroptosis effect has been illuminated with a clear Fenton reaction mechanism that
converts endogenous hydrogen peroxide (H2O2) into highly oxidative hydroxyl radicals …

[HTML][HTML] Biomedical applications of engineered heparin-based materials

EN Zare, D Khorsandi, A Zarepour, H Yilmaz… - Bioactive Materials, 2024 - Elsevier
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic
backbone. Due to its fascinating chemical and physical properties, nontoxicity …