Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

In order to promote an efficient humoral immune response, germinal center B cells modify
both the antigen recognition and effector domains by programmed genetic alterations of …

Sophisticated genetic tools have made possible the identification of the genes responsible
for most well-described immunodeficiencies in the past 15 years. Mutations in Btk …

In response to an assault by foreign organisms, peripheral B cells can change their antibody
affinity and isotype by somatically mutating their genomic DNA. The ability of a cell to modify …

Mammalian cells require non-homologous end joining (NHEJ) for the efficient repair of
chromosomal DNA double-strand breaks. A key feature of biological sources of strand …

Efficient humoral responses rely on DNA damage, mutagenesis and error-prone DNA repair.
Diversification of B cell receptors through somatic hypermutation and class-switch …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …

Activation-induced cytidine deaminase (AID) interacts with replication protein A (RPA), the
major ssDNA-binding protein, to promote deamination of cytosine to uracil in transcribed …

The enzyme activation-induced deaminase (AID) triggers antibody diversification in B cells
by catalyzing deamination and consequently mutation of immunoglobulin genes. To …