It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

The process of cellular differentiation requires the distinct spatial organization of the
microtubule cytoskeleton, the arrangement of which is specific to cell type. Microtubule …

Microtubules are composed of α-tubulin and β-tubulin dimers positioned head-to-tail to form
protofilaments that associate laterally in varying numbers. It is not known how cellular …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Microtubules are essential for intracellular organization and chromosome segregation. They
are nucleated by the γ-tubulin ring complex (γTuRC). However, isolated vertebrate γTuRC …

As the main microtubule-organizing centre in animal cells, the centrosome has a
fundamental role in cell function. Surrounding the centrioles, the pericentriolar material …

How microtubules (MTs) are generated in the cell is a major question in understanding how
the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the …

CDK5RAP2 is a human microcephaly protein that contains a γ-tubulin complex (γ-TuC)–
binding domain conserved in Drosophila melanogaster centrosomin and …

The novel concept of a centrosomal anchoring complex, which is distinct from the γ-tubulin
nucleating complex, has previously been proposed following studies on cochlear epithelial …

Epithelial ovarian cancer (EOC) is hallmarked by a high degree of heterogeneity. To
address this heterogeneity, a classification scheme was developed based on gene …