Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

Episodic memory deficits have increasingly been recognized as a cognitive feature of
depression. To quantify these deficits and determine how they are moderated by various …

Objective: To understand the role of depressive symptoms in preclinical Alzheimer's
disease, it is essential to define their temporal relationship to Alzheimer's proteinopathies in …

Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal
function, which is suggestive of neurogenesis impairments, is associated with depression …

The high symptomatic and biological heterogeneity of major depressive disorder (MDD)
makes it very difficult to find broadly efficacious treatments that work against all symptoms …

Background Neuropathological diagnosis of argyrophilic grain disease (AGD) is currently
based primarily on the combination of argyrophilic grain (AG) visualized using Gallyas …

Subicular regions play important roles in spatial processing and many cognitive functions,
and these are mainly attributed to the subiculum (Sub) rather than the prosubiculum (PS) …

Loneliness is a perception of social and emotional isolation that increases in prevalence
among older adults during the eighth decade of life. Loneliness has been associated with …

Running exercise was shown to have a positive effect on depressive-like symptoms in many
studies, but the underlying mechanism of running exercise in the treatment of depression …

Choice selection strategies and decision-making are typically investigated using multiple-
choice gambling paradigms that require participants to maximize expected value of rewards …