The role of toxins in Clostridium difficile infection

R Chandrasekaran, DB Lacy - FEMS microbiology reviews, 2017 - academic.oup.com
Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-
associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity …

Clostridioides difficile: diagnosis and treatments

B Guery, T Galperine, F Barbut - Bmj, 2019 - bmj.com
Clostridioides difficile (formerly Clostridium) is a major cause of healthcare associated
diarrhea, and is increasingly present in the community. Historically, C difficile infection was …

Host immunity and immunization strategies for Clostridioides difficile infection

F Naz, WA Petri - Clinical Microbiology Reviews, 2023 - journals.asm.org
Clostridioides difficile infection (CDI) represents a significant challenge to public health. C.
difficile-associated mortality and morbidity have led the US CDC to designate it as an urgent …

Host Immune Responses to Clostridioides difficile: Toxins and Beyond

B Nibbering, DN Gerding, EJ Kuijper… - Frontiers in …, 2021 - frontiersin.org
Clostridioides difficile is often resistant to the actions of antibiotics to treat other bacterial
infections and the resulting C. difficile infection (CDI) is among the leading causes of …

Prevalence, genotype and antimicrobial resistance of Clostridium difficile isolates from healthy pets in Eastern China

Y Wei, M Sun, Y Zhang, J Gao, F Kong, D Liu… - BMC infectious …, 2019 - Springer
Background Clostridium difficile (C. difficile) is a main cause of antibiotic-associated
diarrhoea in humans. Several studies have been performed to reveal the prevalence rate of …

[HTML][HTML] Host Immune Responses to Clostridioides difficile Infection and Potential Novel Therapeutic Approaches

MZ Alam, JE Markantonis, JT Fallon - Tropical Medicine and Infectious …, 2023 - mdpi.com
Clostridioides difficile infection (CDI) is a leading nosocomial infection, posing a substantial
public health challenge within the United States and globally. CDI typically occurs in …

Immunization Strategies Against Clostridioides difficile

C Campidelli, JF Bruxelle, A Collignon… - … on Clostridioides difficile …, 2024 - Springer
Clostridioides difficile (C. difficile) infection (CDI) is an important healthcare but also a
community-associated disease. CDI is considered a public health threat and an economic …

The state of play of rodent models for the study of Clostridioides difficile infection

A Brosse, H Coullon, C Janoir… - Journal of Medical …, 2024 - microbiologyresearch.org
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhoea and is responsible for a spectrum of diseases characterized by high levels of …

A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile

D Sapa, A Brosse, H Coullon, G Péan de Ponfilly… - Toxins, 2024 - mdpi.com
The major virulence factors of Clostridioides difficile (C. difficile) are enterotoxins A (TcdA)
and B (TcdB). The study of toxins is a crucial step in exploring the virulence of this pathogen …

Immunogenicity of a recombinant chimera composed of CROP domain segments from the hemorrhagic and lethal toxins of Paeniclostridium sordellii

RR Rodrigues, N Conrad, MRA Ferreira, CM Júnior… - Anaerobe, 2025 - Elsevier
Paeniclostridium sordellii is responsible for severe infections in horses, cattle, and sheep,
however, conventional vaccines exhibit limitations in production and immunogenicity. This …