[HTML][HTML] The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy
F Ardito, M Giuliani, D Perrone… - International …, 2017 - spandidos-publications.com
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …
Classification of intrinsically disordered regions and proteins
Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …
An atlas of substrate specificities for the human serine/threonine kinome
Protein phosphorylation is one of the most widespread post-translational modifications in
biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …
biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
Abstract PhosphoSitePlus®(PSP, http://www. phosphosite. org/), a knowledgebase
dedicated to mammalian post-translational modifications (PTMs), contains over 330 000 non …
dedicated to mammalian post-translational modifications (PTMs), contains over 330 000 non …
Illuminating the dark phosphoproteome
Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …
This was first recognized through functional biochemical experiments, and in the past …
Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates
DF Egan, MGH Chun, M Vamos, H Zou, J Rong… - Molecular cell, 2015 - cell.com
Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy
as a potential broadly applicable cancer therapy. ULK1/Atg1 is the only serine/threonine …
as a potential broadly applicable cancer therapy. ULK1/Atg1 is the only serine/threonine …
Non-histone protein methylation as a regulator of cellular signalling and function
Abstract Methylation of Lys and Arg residues on non-histone proteins has emerged as a
prevalent post-translational modification and as an important regulator of cellular signal …
prevalent post-translational modification and as an important regulator of cellular signal …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
[HTML][HTML] A tissue-specific atlas of mouse protein phosphorylation and expression
Although most tissues in an organism are genetically identical, the biochemistry of each is
optimized to fulfill its unique physiological roles, with important consequences for human …
optimized to fulfill its unique physiological roles, with important consequences for human …
Status of large-scale analysis of post-translational modifications by mass spectrometry
Cellular function can be controlled through the gene expression program, but often protein
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …