Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …

To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …

The discovery that transient elevations of calcium concentration occur in astrocytes, and
release'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea …

Noradrenaline (NA) release from the locus coeruleus (LC) changes activity and connectivity
in neuronal networks across the brain, modulating multiple behavioral states. NA release is …

Data collected on astrocytes' physiology in the rodent have placed them as key regulators of
synaptic, neuronal, network, and cognitive functions. While these findings proved highly …

Astrocytes are highly complex cells with many emerging putative roles in brain function. Of
these, gliotransmission (active information transfer from glia to neurons) has probably the …

The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …

Intracellular Ca2+ signaling is considered to be important for multiple astrocyte functions in
neural circuits. However, mice devoid of inositol triphosphate type 2 receptors (IP3R2) …