Coumarin: A natural, privileged and versatile scaffold for bioactive compounds
Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Current developments of coumarin compounds in medicinal chemistry
XM Peng, G LV Damu, C He Zhou - Current pharmaceutical …, 2013 - benthamdirect.com
Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …
Privileged scaffolds as MAO inhibitors: Retrospect and prospects
This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …
general interest to the medicinal chemistry community because it focuses on the …
New frontiers in selective human MAO-B inhibitors: miniperspective
S Carradori, R Silvestri - Journal of medicinal chemistry, 2015 - ACS Publications
Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease
Monoamine oxidase (MAO) enzyme inhibition is a crucial target for the management of
depression and Alzheimer disease and inhibitors of MAO are the most important drugs for …
depression and Alzheimer disease and inhibitors of MAO are the most important drugs for …
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease
SS **e, X Wang, N Jiang, W Yu, KDG Wang… - European Journal of …, 2015 - Elsevier
A series of novel tacrine-coumarin hybrids were designed, synthesized and evaluated as
multi-target agents against Alzheimer's disease. The biological assays indicated that most of …
multi-target agents against Alzheimer's disease. The biological assays indicated that most of …
Monoamine oxidase B inhibitors based on natural privileged scaffolds: A review of systematically structural modification
Y Lv, Z Zheng, R Liu, J Guo, C Zhang, Y **e - International Journal of …, 2023 - Elsevier
Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …
Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation
A series of new coumarin-dithiocarbamate hybrids were designed and synthesized as
multitarget agents for the treatment of Alzheimer's disease. Most of them showed potent and …
multitarget agents for the treatment of Alzheimer's disease. Most of them showed potent and …
Implication of coumarins towards central nervous system disorders
Coumarins are widely distributed, plant-derived, 2 H-1-benzopyran-2-one derivatives which
have attracted intense interest in recent years as a result of their diverse and potent …
have attracted intense interest in recent years as a result of their diverse and potent …