New molecular modeling approaches, driven by rapidly improving computational platforms,
have allowed many success stories for the use of computer-assisted drug design in the …

With approximately 1% of proteins being flavoproteins, flavins are at the heart of a plethora
of redox reactions in all areas of biology. Thanks to a series of fascinating recent …

Ubiquinone (also known as coenzyme Q) is a ubiquitous lipid-soluble redox cofactor that is
an essential component of electron transfer chains. Eleven genes have been implicated in …

Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …

Epoxide ring opening reactions are common and important in both biological processes and
synthetic applications and can be catalyzed in a non-redox manner by epoxide hydrolases …

Due to the chemical versatility of the flavin cofactor, FMN-dependent ene-reductases and
nitro-reductases can catalyze or mediate a diverse spectrum of chemical reactions. Among …

Prenylated flavin mononucleotide (prFMN) is a recently discovered cofactor required by the
UbiD family of reversible decarboxylases involved in ubiquinone biosynthesis, biological …

Background Riboflavin is the precursor of several cofactors essential for normal physical
and cognitive development, but only plants and some microorganisms can produce it …

Flavin-dependent enzymes catalyze a wide variety of biological reactions that are important
for all types of living organisms. Knowledge gained from studying the chemistry and …

The flavoenzyme UDP-galactopyranose mutase (UGM) is a key enzyme in galactofuranose
biosynthesis. The enzyme catalyzes the 6-to-5 ring contraction of UDP-galactopyranose to …