Axon loss is a shared feature of nervous systems being challenged in neurological disease,
by chemotherapy or mechanical force. Axons take up the vast majority of the neuronal …

The ability to sense the world, process information, and navigate the environment depends
on the assembly and continuous function of neural circuits in the brain. Within the past two …

When a neurotrophin binds at the presynapse, it sends survival signals all the way to the
nucleus on signaling endosomes. These endosomes fuel their own journey with on-board …

Axon degeneration contributes to the disruption of neuronal circuit function in diseased and
injured nervous systems. Severed axons degenerate following the activation of an …

Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular
matrix (ECM) and basement membrane (BM) and have both structural and signaling roles …

Synaptic positions underlie precise circuit connectivity. Synaptic positions can be
established during embryogenesis and sustained during growth. The mechanisms that …

Mature neurons maintain their distinctive morphology for extended periods in adult life.
Compared to developmental neurite outgrowth, axon guidance, and target selection …

Axon degeneration is a shared feature in neurodegenerative disease and when nervous
systems are challenged by mechanical or chemical forces. However, our understanding of …

Peripheral somatosensory neurons innervate the skin and sense the environment. Whereas
many studies focus on initial axon outgrowth and pathfinding, how signaling pathways …

Neuronal architecture established embryonically must persist lifelong to ensure normal brain
function. However, little is understood about the mechanisms behind the long-term …