The poor prognosis and rising incidence of esophageal cancer highlight the need for
improved detection and prediction methods that are essential prior to treatment. Esophageal …

Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …

Endothelial dysfunction induced by hyperhomocysteinemia (HHcy) plays a critical role in
vascular pathology. However, little is known about the role of endoplasmic reticulum (ER) …

Background Glutathione peroxidases (GPXs) are an enzyme family with peroxidase activity.
Abnormal GPX expression is associated with carcinogenesis. However, the potential role of …

Background The liver plays a central role in the maintenance of homeostasis and health in
general. However, there is substantial inter-individual variation in hepatic gene expression …

Oxidative stress is increasingly recognized as a central player in a range of gastrointestinal
(GI) disorders, as well as complications stemming from therapeutic interventions. This article …

Objective While oesophageal squamous cell carcinoma remains infrequent in Western
populations, the incidence of oesophageal adenocarcinoma (EAC) has increased sixfold to …

Background Clear cell renal cell carcinoma (ccRCC), with its hallmark phenotype of high
cytosolic lipid content, is considered a metabolic cancer. Despite the implication of this lipid …

Maintenance of cellular redox control is pivotal for normal cellular functions and cell fate
decisions including cell death. Among the key cellular redox systems in mammals, the …

Esophageal adenocarcinoma (EAC), the predominant type of esophageal cancer in the
United States, develops through Barrett's esophagus (BE)-dysplasia-carcinoma cascade …