In mammalian systems, skeletal muscle exists in a dynamic state that monitors and regulates
the physiological investment in muscle size to meet the current level of functional demand …

Skeletal muscle possesses remarkable ability to change its size and force-producing
capacity in response to physiological stimuli. Impairment of the cellular processes that …

Rotator cuff tears represent a large burden of muscle-tendon injuries in our aging
population. While small tears can be repaired surgically with good outcomes, critical size …

Transforming Growth Factor β (TGF-β) is involved in fibrosis as well as the regulation of
muscle mass, and contributes to the progressive pathology of muscle wasting disorders …

Targeted differentiation of pluripotent stem (PS) cells into myotubes enables in vitro disease
modeling of skeletal muscle diseases. Although various protocols achieve myogenic …

HHcy has been implicated in elderly frailty, but the underlying mechanisms are poorly
understood. Using C57 and CBS+/− mice and C2C12 cell line, we investigated mechanisms …

Background: Neo-adjuvant chemotherapy is an effective strategy for improving treatment of
breast cancers. However, the efficacy of this treatment strategy is limited for treatment of …

Simultaneous inhibition of transforming growth factor‐β (TGF‐β) type I receptors Acvr1b and
Tgfbr1 signalling has been associated with excessive skeletal muscle hypertrophy in vivo …

During development, muscle growth is usually finely adapted to meet functional demands in
daily activities. However, how muscle geometry changes in typically develo** children …

Myogenic differentiation is a complex and well-coordinated process for generating mature
skeletal muscle fibers. This event is autocrine/paracrine regulated by growth factors …