Studies of the processes leading to the construction of a bud and its separation from the
mother cell in Saccharomyces cerevisiae have provided foundational paradigms for the …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Computational modeling and the theory of nonlinear dynamical systems allow one to not
simply describe the events of the cell cycle, but also to understand why these events occur …

The adaptive responses of a living cell to internal and external signals are controlled by
networks of proteins whose interactions are so complex that the functional integration of the …

One of the early success stories of computational systems biology was the work done on cell-
cycle regulation. The earliest mathematical descriptions of cell-cycle control evolved into …

Different cancer cell lines can have varying responses to the same perturbations or stressful
conditions. Cancer cells that have DNA damage checkpoint-related mutations are often …

We propose a protein interaction network for the regulation of DNA synthesis and mitosis
that emphasizes the universality of the regulatory system among eukaryotic cells. The …

Background Signal transduction pathways are usually modelled using classical quantitative
methods, which are based on ordinary differential equations (ODEs). However, some …

Cellular networks are composed of complicated interconnections among components, and
some subnetworks of particular functioning are often identified as network motifs. Among …

Intracellular biochemical parameters, such as the expression level of gene products, are
considered to be optimized so that a biological system, including the parameters, works …