Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Currently, the clinical treatment of critical bone defects attributed to various causes remains
a great challenge, and repairing these defects with synthetic bone substitutes is the most …

Over the last decade, adipose‐derived stem cells (ADSCs) have attracted increasing
attention in the field of regenerative medicine. ADSCs appear to be the most advantageous …

Tissue/organ shortage is a major medical challenge due to donor scarcity and patient
immune rejections. Furthermore, it is difficult to predict or mimic the human disease condition …

The utilization of marine-based collagen is growing fast due to its unique properties in
comparison with mammalian-based collagen such as no risk of transmitting diseases, a lack …

The goal of a biomaterial is to support the bone tissue regeneration process at the defect site
and eventually degrade in situ and get replaced with the newly generated bone tissue …

Research and development of the ideal artificial bone-substitute materials to replace
autologous and allogeneic bones for repairing bone defects is still a challenge in clinical …

For bone defect repair under co-morbidity conditions, the use of biomaterials that can be non-
invasively regulated is highly desirable to avoid further complications and to promote …

Critical-sized bone defect repair remains a substantial challenge in clinical settings and
requires bone grafts or bone substitute materials. However, existing biomaterials often do …

Traditional orthopedic metal implants, such as titanium (Ti), Ti alloys, and cobalt-chromium
(Co-Cr) alloys, cannot be degraded in vivo. Fracture patients is must always suffer a second …