The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

Adipocytes are the defining cell type of adipose tissue. Once considered a passive
participant in energy storage, adipose tissue is now recognized as a dynamic organ that …

Leptin receptor (LepR)‐positive cells are key components of the bone marrow hematopoietic
microenvironment, and highly enrich skeletal stem and progenitor cells that maintain …

The relationship between bone and fat formation within the bone marrow microenvironment
is complex and remains an area of active investigation. Classical in vitro and in vivo studies …

Bone marrow adipogenesis is a normal physiologic process in all mammals. However, its
function is unknown. The mesenchymal stem cell is the marrow precursor for adipocytes as …

Objective Glucocorticoid (GC) excess induces alterations in bone metabolism that weaken
bone structure and increase fracture risk. The aim of this study was to identify genes …

Abstract Type I (T1) diabetes, also called insulin dependent diabetes mellitus (IDDM), is
characterized by little or no insulin production and hyperglycemia. One of the less well …

Abstract Purpose of Review Bone elongation is a complex process driven by multiple
intrinsic (hormones, growth factors) and extrinsic (nutrition, environment) variables. Bones …

The belief that obesity is protective against osteoporosis has recently come into question.
The latest epidemiologic and clinical studies have shown that a high level of fat mass might …

Thyroid hormone (TH) is essential for vertebrate development and the homeostasis of most
adult tissues, including bone. TH stimulates target gene expression through the nuclear …