Enhancing cellular immunotherapies in cancer by engineering selective therapeutic resistance
Adoptive cell therapies engineered to express chimeric antigen receptors (CARs) or
transgenic T cell receptors (TCRs) to recognize and eliminate cancer cells have emerged as …
transgenic T cell receptors (TCRs) to recognize and eliminate cancer cells have emerged as …
New strategies to treat AML: novel insights into AML survival pathways and combination therapies
R Nair, A Salinas-Illarena, HM Baldauf - Leukemia, 2021 - nature.com
The effective treatment of acute myeloid leukemia (AML) is very challenging. Due to the
immense heterogeneity of this disease, treating it using a “one size fits all” approach is …
immense heterogeneity of this disease, treating it using a “one size fits all” approach is …
An integrated genome-wide CRISPRa approach to functionalize lncRNAs in drug resistance
Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic
units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia …
units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia …
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
The onset of inflammation is associated with reactive oxygen species and oxidative damage
to macromolecules like 7, 8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …
to macromolecules like 7, 8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …
SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by
CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …
CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …
Nucleobase and nucleoside analogues: resistance and re-sensitisation at the level of pharmacokinetics, pharmacodynamics and metabolism
Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs
that, starting from the small field of paediatric oncology, in combination with other …
that, starting from the small field of paediatric oncology, in combination with other …
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner
T Schumann, SC Ramon, N Schubert… - Journal of Experimental …, 2022 - rupress.org
Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …
SAMHD1 functions and human diseases
SAA Coggins, B Mahboubi, RF Schinazi, B Kim - Viruses, 2020 - mdpi.com
Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
maintenance of genomic information in both cells and a variety of viral pathogens. While the …
Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia
VY Ling, J Straube, W Godfrey, R Haldar… - Leukemia, 2023 - nature.com
Chemotherapy-resistant acute myeloid leukemia (AML), frequently driven by clonal
evolution, has a dismal prognosis. A genome-wide CRISPR knockout screen investigating …
evolution, has a dismal prognosis. A genome-wide CRISPR knockout screen investigating …
De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity
J Liu, T Zhou, X Dong, Q Guo, L Zheng, X Wang… - Oncogene, 2023 - nature.com
Oncogenic stress induces DNA damage repair (DDR) that permits escape from mitotic
catastrophe and allows early precursor lesions during the evolution of cancer. SAMHD1, a …
catastrophe and allows early precursor lesions during the evolution of cancer. SAMHD1, a …