Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
Metals exposures and DNA methylation: current evidence and future directions
Abstract Purpose of the Review Exposure to essential and non-essential metals is
widespread. Metals exposure is linked to epigenetic, particularly DNA methylation …
widespread. Metals exposure is linked to epigenetic, particularly DNA methylation …
Introduction to epigenetics
Epigenetics is the study of inherited variations in gene expression that do not involve
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …
DNA hydroxymethylation reprogramming of β-oxidation genes mediates early-life arsenic-evoked hepatic lipid accumulation in adult mice
YP Song, JW Lv, Y Zhao, X Chen, ZC Zhang… - Journal of Hazardous …, 2022 - Elsevier
The metabolic disorders are becoming an epidemic disease endangering public health in
countries. Environmental factors are mainly reason for the growth of metabolic disorders …
countries. Environmental factors are mainly reason for the growth of metabolic disorders …
piOxi database: a web resource of germline and somatic tissue piRNAs identified by chemical oxidation
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that are highly
expressed and extensively studied from the germline. piRNAs associate with PIWI proteins …
expressed and extensively studied from the germline. piRNAs associate with PIWI proteins …
Perinatal lead exposure promotes sex-specific epigenetic programming of disease-relevant pathways in mouse heart
Environmental contaminants such as the metal lead (Pb) are associated with cardiovascular
disease, but the underlying molecular mechanisms are poorly understood. In particular, little …
disease, but the underlying molecular mechanisms are poorly understood. In particular, little …
The effects of age, origin, and biological sex on rodent mast cell (BMMC and MC/9) and basophil (RBL-2H3) phenotype and function
Mast cells initiate allergic inflammatory immune responses and play a role in disease by
releasing various inflammatory and immunomodulatory mediators. Several mast cell-lines …
releasing various inflammatory and immunomodulatory mediators. Several mast cell-lines …
Prenatal environmental stressors and DNA methylation levels in placenta and peripheral tissues of mothers and neonates evaluated by applying artificial neural …
Exposure to environmental stressors during pregnancy plays an important role in influencing
subsequent susceptibility to certain chronic diseases through the modulation of epigenetic …
subsequent susceptibility to certain chronic diseases through the modulation of epigenetic …
Toxicoepigenetics and environmental health: Challenges and opportunities
The rapidly growing field of toxicoepigenetics seeks to understand how toxicant exposures
interact with the epigenome to influence disease risk. Toxicoepigenetics is a promising field …
interact with the epigenome to influence disease risk. Toxicoepigenetics is a promising field …
Sex-specific alterations in cardiac DNA methylation in adult mice by perinatal lead exposure
Environmental factors play an important role in the etiology of cardiovascular diseases.
Cardiovascular diseases exhibit marked sexual dimorphism; however, the sex-specific …
Cardiovascular diseases exhibit marked sexual dimorphism; however, the sex-specific …