Recognition in the domain of molecular chirality: from noncovalent interactions to separation of enantiomers

P Peluso, B Chankvetadze - Chemical Reviews, 2022 - ACS Publications
It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in
nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules …

Native and substituted cyclodextrins as chiral selectors for capillary electrophoresis enantioseparations: Structures, features, application, and molecular modeling

P Peluso, B Chankvetadze - Electrophoresis, 2021 - Wiley Online Library
CDs are cyclic oligosaccharides consisting of α‐d‐glucopyranosyl units linked through 1, 4‐
linkages, which are obtained from enzymatic degradation of starch. The coexistence of …

Advances in the use of cyclodextrins as chiral selectors in capillary electrokinetic chromatography: fundamentals and applications

Q Zhu, GKE Scriba - Chromatographia, 2016 - Springer
Capillary electrokinetic chromatography is generally recognized as a versatile and robust
capillary electromigration technique for the separation of enantiomers. In this mode, one or …

Cyclodextrin-assisted SERS determination of fluoroquinolone antibiotics in urine and blood plasma

NE Markina, AV Markin, D Cialla-May - Talanta, 2023 - Elsevier
This paper describes the use of cyclodextrins (CDs) to improve the determination of
fluoroquinolone antibiotics in human body fluids using surface-enhanced Raman …

Cyclodextrins in capillary electrophoresis: recent developments and new trends

L Escuder-Gilabert, Y Martín-Biosca… - … of Chromatography A, 2014 - Elsevier
Despite the fact that extensive research in the field of separations by capillary
electrophoresis (CE) has been carried out and many reviews have been published in the …

[HTML][HTML] Enantioseparation of ofloxacin using a liquid–liquid extraction system based on hydrophobic eutectic solvents

M Moradi, AM Ferreira, CMSS Neves, FHB Sosa… - Separation and …, 2025 - Elsevier
The enantioseparation of chiral drugs is a major challenge for the pharmaceutical industry
as the pharmacological activities of the enantiomers may differ, which can lead to severe …

Characterization of thymoquinone/hydroxypropyl-β-cyclodextrin inclusion complex: Application to anti-allergy properties

MS Al-Qubaisi, A Rasedee, MH Flaifel, EEM Eid… - European Journal of …, 2019 - Elsevier
Thymoquinone is an effective phytochemical compound in the treatment of various diseases.
However, its practical administration has been limited due to poor aqueous solubility and …

Characteristic of Cyclodextrins: Their role and use in the pharmaceutical technology

M Lachowicz, A Stańczak… - Current Drug Targets, 2020 - ingentaconnect.com
About 40% of newly-discovered entities are poorly soluble in water, and this may be an
obstacle in the creation of new drugs. To address this problem, the present review article …

Thermodynamics and molecular insight in guest–host complexes of fluoroquinolones with β-cyclodextrin derivatives, as revealed by ATR-FTIR spectroscopy and …

IM Le-Deygen, AA Skuredina, IV Uporov… - Analytical and …, 2017 - Springer
Abstract β-Сyclodextrin (CD) is a perspective class of excipients used in pharmaceutical
formulations to enhance solubility, bioavailability, and pharmacokinetics of various poorly …

Applications of nuclear magnetic resonance spectroscopy for the understanding of enantiomer separation mechanisms in capillary electrophoresis

A Salgado, B Chankvetadze - Journal of Chromatography A, 2016 - Elsevier
This review deals with the applications of nuclear magnetic resonance (NMR) spectroscopy
to understand the mechanisms of chiral separation in capillary electrophoresis (CE). It is …