[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
Cellular senescence: defining a path forward
Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
The regulation and functions of DNA and RNA G-quadruplexes
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …
structures form through self-recognition of guanines into stacked tetrads, and considerable …
Overcoming cancer therapeutic bottleneck by drug repurposing
Z Zhang, L Zhou, N ** human telomeres: from shelterin and CST complexes to telomeric chromatin organization
The regulation of telomere length in mammals is crucial for chromosome end-cap** and
thus for maintaining genome stability and cellular lifespan. This process requires …
thus for maintaining genome stability and cellular lifespan. This process requires …
Determinants of telomere length across human tissues
K Demanelis, F Jasmine, LS Chen, M Chernoff, L Tong… - Science, 2020 - science.org
INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …
that protect chromosome ends from degradation and fusion. The DNA component of …
Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players
X Yuan, C Larsson, D Xu - Oncogene, 2019 - nature.com
Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …
Aneuploidy in mammalian oocytes and the impact of maternal ageing
C Charalambous, A Webster, M Schuh - Nature Reviews Molecular Cell …, 2023 - nature.com
During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …
each chromosome to the embryo. However, human eggs frequently contain an incorrect …