Objective To determine the relative efficacy of structured named diet and health behaviour
programmes (dietary programmes) for prevention of mortality and major cardiovascular …

Ventilator-free days (VFDs) are a commonly reported composite outcome measure in acute
respiratory distress syndrome trials. VFDs combine survival and duration of ventilation in a …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Background: A composite metric for the quality of glycemia from continuous glucose monitor
(CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data …

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Background Antibiotics alter the microbial balance commonly resulting in antibiotic‐
associated diarrhea (AAD). Probiotics may prevent AAD via providing gut barrier, restoration …

Correctable weaknesses in the design, conduct, and analysis of biomedical and public
health research studies can produce misleading results and waste valuable resources …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …

In clinical trials it is not uncommon to face a multiple testing problem which can have an
impact on both type I and type II error rates, leading to inappropriate interpretation of trial …

Clinical research should ultimately improve patient care. For this to be possible, trials must
evaluate outcomes that genuinely reflect real-world settings and concerns. However, many …